John R. Middleton
Assistant Professor, Food Animal Medicine and Surgery

· DVM, Washington State University, Pullman, WA
· PhD, Washington State University, Pullman, WA

· Diplomate, American College of Veterinary Internal Medicine (ACVIM) (Large Animal Internal Medicine)

MiddletonJr@missouri.edu

Research interests:

Mastitis prevention, control and treatment
Methicillin resistant Staphylococcus aureus

Teaching:  Large animal medicine and surgery

Selected publications:

Middleton JR, Luby CD. Escherichia coli mastitis in cattle being treated for Staphylococcus aureus intramammary infection. Vet Rec. 2008; 162(5):156-7. [No abstract available]  

Mavangira V, Hughes JM, Middleton JR, Mitchell WJ, Kim DY.  Malignant melanoma of the horn base in a Pygora goat. J Vet Diagn Invest 2008; 20(1):104-07.  [Abstract]

Luby CD, Middleton JR, Youngquist RS, Kim DY, Evans AT. Theriogenology question of the month. Sertoli cell tumor. J Am Vet Med Assoc 2007; 231(10):1503-05. [No abstract available]

Chigerwe M, Middleton JR, Williams F 3rd, Tyler JW, Kreeger JM.  Atypical coccidiosis in South American camelids.  J Vet Diagn Invest 2007; 19(1):122-25.  [Abstract]

Luby CD, Middleton JR, Ma J, Rinehart CL, Bucklin S, Kohler C, Tyler JW.  Characterization of the antibody isotype response in serum and milk of heifers vaccinated with a Staphylococcus aureus bacterin (Lysigin).  J Dairy Res 2007; 74(2):239-46.  [Abstract]

Lakritz J, Middleton JR, Anderson DE, Linden DR, Sams RA, Tessman RK, Tyler JW. Pharmacokinetics of intravenously administered caffeine in healthy alpacas (Lama pacos) and llamas (Lama glama). Am J Vet Res 2006; 67(6):1063-69.  [Abstract]

Middleton JR, Chigerwe M, Fine DM, Turk JR, Lattimer JC.  Pulmonary hypertension and right-sided heart failure in an adult llama with hepatic disease. J Am Vet Med Assoc 2006; 228(5):756-59.  [Abstract]

Middleton JR, Johnson GC, Pardo I, Chigerwe M, O'Brien DP.  Dysautonomia and salmonellosis in an 11-year-old female llama (Lama glama). J Vet Intern Med. 2006; 20(1):213-16. [No abstract available]

Middleton JR, Ma J, Rinehart CL, Taylor VN, Luby CD, Steevens BJ.  Efficacy of different Lysigin formulations in the prevention of Staphylococcus aureus intramammary infection in dairy heifers.  J Dairy Res 2006; 73(1):10-19.    [Abstract]

Middleton JR, Timms LL, Bader GR, Lakritz J, Luby CD, Steevens BJ.  Effect of prepartum intramammary treatment with pirlimycin hydrochloride on prevalence of early first-lactation mastitis in dairy heifers. J Am Vet Med Assoc. 2005; 227(12):1969-74.  [Abstract]

Middleton JR, Moody MM, Parish SM.  Diabetes mellitus in an adult alpaca (Lama pacos). Vet Rec 2005; 157(17):520-22. [No abstract available]

Luby CD, Middleton JR.  Efficacy of vaccination and antibiotic therapy against Staphylococcus aureus mastitis in dairy cattle.  Vet Rec 2005; 157(3):89-90. [No abstract available]

Middleton JR, Fales WH, Luby CD, Oaks JL, Sanchez S, Kinyon JM, Wu CC, Maddox CW, Welsh RD, Hartmann F.  Surveillance of Staphylococcus aureus in veterinary teaching hospitals. J Clin Microbiol 2005; 43(6):2916-19.  [Abstract]

Middleton JR, Hardin D, Steevens B, Randle R, Tyler JW. Use of somatic cell counts and California mastitis test results from individual quarter milk samples to detect subclinical intramammary infection in dairy cattle from a herd with a high bulk tank somatic cell count.  J Am Vet Med Assoc 2004; 224(3):419-23.  [Abstract]

Tyler JW, Middleton JR. Transmissible spongiform encephalopathies in ruminants. Vet Clin North Am Food Anim Pract. 2004; 20(2):303-26. [Abstract]

Middleton JR, Hebert VR, Fox LK, Tomaszewska E, Lakritz J.  Elimination kinetics of chlorhexidine in milk following intramammary infusion to stop lactation in mastitic mammary gland quarters of cows. J Am Vet Med Assoc 2003; 222(12):1746-49.  [Abstract]

Hebert VR, Middleton JR, Tomaszewska E, Fox LK.  Methodology for quantifying residues of chlorhexidine in raw dairy milk.  J Agric Food Chem. 2003; 51(3):567-70.  [Abstract]

Middleton JR, LK Fox.  Influence of Staphylococcus aureus strain on mammary quarter milk production.  Vet Rec 2002;150:13:411-13. [Abstract]

Middleton JR, LK Fox, JM Gay, JW Tyler, TE Besser.  Influence of Staphylococcus aureus strain-type on mammary quarter milk somatic cell count and N-acetyl-B-D-glucosaminidase activity in cattle from eight dairies.  J Dairy Sci 2002; 85(5):1133-40.  [Abstract]

Middleton JR, Fox LK, Gay JM, Tyler JW, Besser TE.  Use of pulsed-field gel electrophoresis for detecting differences in Staphylococcus aureus strain populations between dairy herds with different cattle importation practices.  Epidemiology and Infection 2002; 129(2):387-95. [Abstract]

Middleton JR, Fox LK, Smith TH.  Management strategies to decrease the prevalence of mastitis caused by one strain of Staphylococcus aureus in a dairy herd.  J Am Vet Med Assoc 2001; 218(10):1615-18.  [Abstract]

Middleton JR, Fox LK.  Therapeutic cessation of lactation of Staphylococcus aureus-infected mammary quarters.  J Dairy Sci. 2001; 84(9):1976-78. [Abstract]

Middleton JR, Valdez R, Britt LG, Parish SM, Tyler JW.  Progressive hindlimb paraparesis in a goat associated with a vascular hamartoma.  Vet Rec 1999; 144(10):264-65.  [Abstract]

Middleton JR, Parish SM.  Heat stress in a llama (Lama glama): A case report and review of the syndrome.  Journal of Camel Practice and Research 1999; 6(2):265-69.  [Abstract]

Middleton JR.  Hematology of South American camelidae.  Journal of Camel Practice and Research 1999; 6(2):153-58. [Abstract]

Smith TH, Fox LK, Middleton JR .  Outbreak of mastitis caused by one strain of Staphylococcus aureus in a closed dairy herd.  J Am Vet Med Assoc 1998; 212(4):553-56.  [Abstract]

Middleton JR, Katz L, Angelos JA, Tyler JW.  Hemolysis associated with water administration using a nipple bottle for human infants in juvenile pygmy goats.  J Vet Int Med 1997; 11(6):382-84.  [Abstract]