Dennis P. O’Brien
    Professor of Neurology
    Small Animal Medicine and Surgery

· BS (with honors), University of Illinois, Urbana, IL
· DVM (with honors), University of Illinois, Urbana, IL
· MS (Veterinary Clinical Medicine), University of Illinois, Urbana, IL
· PhD (Neuroscience) University of Illinois, Urbana, IL

· Diplomate, American College of Veterinary Internal Medicine (ACVIM) (Specialty of Neurology)

OBrienD@missouri.edu

Research emphasis:

Research has focused on hereditary and acquired neurodegenerative diseases of domestic animals. Particular areas of focus have been epilepsy, movement disorders and dysautonomia.

Teaching:  Neurology

Selected publications:

Refereed journals:

Katz ML, Coates JR, Cooper JJ, O'Brien DP, Jeong M, Narfstrom K.  Retinal pathology in a canine model of late infantile neuronal ceroid lipofuscinosis.  Invest Ophthalmol Vis Sci 2008; [In press].

Moore SA, O'Brien DP.  Canine pituitary macrotumors.  Compend Contin Educ Vet 30(1):33-41, 2008. [In press].

Chen X, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Parker HG, Patterson EE, Awano T, Khan S, O'Brien DP: A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2.  Neurogenetics 9(1):41-9, 2008. [Abstract]

Coates JR, March PA, Oglesbee M, Ruaux CG, Olby NJ, Berghaus RD, O’Brien DP, Keating JH, Johnson GS, Williams DA: Clinical characterization of degenerative myelopathy in 21 Pembroke Welsh Corgi dogs. J Vet Intern Med 21:1332-1339, 2007. [Abstract]

Packer RA, Bergman RL, Coates JR, Essman SC, Weis K, O’Brien DP, Johnson GC: Intracranial subarachnoid hemorrhage following lumbar myelopathy in two dogs. Vet Rad Ultrasound 48(4):323-327, 2007. [Abstract]

Awano T, Katz, ML, O’Brien DP, Evans J, Sohar I, Lobel P, Coates JR, Khan S, Johnson GS: A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis. Mol Genet Metab 89(3):254-60, 2006. [Abstract]

Awano T, Katz, ML, O’Brien DP, Taylor JF, Evans J, Khan S, Sohar I, Lobel P, Johnson GS:  A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis. Mol Genet Metab 87:341-8, 2006. [Abstract]

Middleton JR, Johnson GC, Pardo I, Chigerwe M, O’Brien DP: Dysautonomia and Salmonellosis in an 11-Year-Old Female Llama (Lama glama). J Vet Intern Med 20:213-6, 2006.[Abstract]

O’Brien DP, Johnson GS, Schnabel RD, Khan S, Coates JR, Johnson GC, and Taylor JF: Genetic linkage mapping of the canine multiple system degeneration and ectodermal dysplasia loci. J Heredity 96:727-734, 2005. [Abstract]

Patterson EE, Armstrong PJ, O’Brien DP, Roberts MC, Johnson GS, Mickelson JR: Clinical Description and Inheritance of Idiopathic Epilepsy in English Springer Spaniels. JAVMA 226(1):54-8, 2005. [Abstract]

Katz ML, Narfstrom K, O’Brien DP: Assessment of retinal function and characterization of lysosomal storage body accumulation in the retinas and brains of Tibetan Terriers with ceroid-lipofuscinosis. Am J Vet Res 66:67-76, 2005. [Abstract]

Evans J, Katz ML, Levesque D, Shelton GD, deLahunta A, O’Brien DP: A Variant Form of Neuronal Ceroid Lipofuscinosis in American Bulldogs. J Vet Intern Med 19:44-51, 2005. [Abstract]

Packer RA, Cohn LA, Wohlstadter DR, Shelton GD, Naylor JM, Zello GA, Ewaschuk JB, Williams DA, Raux, CG, O’Brien DP: D-lactic acidosis secondary to exocrine pancreatic insufficiency in a cat. J Vet Intern Med 19:106-110, 2005. [Abstract]

Keegan K, Arafat A, Skubic M, Wilson D, Kramer J, Messer N, Johnson P, O'Brien DP and Johnson G: Detection of spinal ataxia in horses using fuzzy clustering of body position uncertainty. Equine Vet J  36:712-7, 2004. [Abstract]

Olby N, Blot S, Thibaud JL, Phillips J, O'Brien DP, Burr J, Berg J, Brown T, Breen M.  Cerebellar cortical degeneration in adult American Staffordshire Terriers.  J Vet Intern Med 18(2):201-08, 2004.  [Abstract]

Patterson EE, Mickelson JR, Da Y, Roberts MC, McVey AS, O'Brien DP, Johnson GS, Armstrong PJ: Clinical characteristics and inheritance of idiopathic epilepsy in Vizslas. J Vet Intern Med17(3):319-25, 2003. [Abstract]

Coates JR, O'Brien DP, Kline KL, Storts RW, Johnson GC, Shelton GD, Patterson EE, Abbott LC: Neonatal cerebellar ataxia in Coton de Tulear Dogs. J Vet Intern Med 16:680-689, 2002.  [Abstract]

Berghaus RD, O'Brien DP, Thorne JG, Buening GM:  Incidence of canine dysautonomia in Missouri, USA, between January 1996 and December 2000.  Prev Vet Med 54:291-300, 2002.   [Abstract]

O'Brien DP, Johnson GC:  Dysautonomia and autnonmic neuropathies.  Vet Clin North Am Small Anim Pract 32:251-265, 2002.  [Abstract]

O’Brien DP, Johnson GC, Liu LA, Gau LT, Engvall E, Powell HC, Shelton GD:  Laminin alpha 2 (merosin)-deficient muscular dystrophy and demyelinating neuropathy in two cats.  J Neuro Sci 189:37-43, 2001.  [Abstract]

Berghaus RD, O’Brien DP, Johnson GC, Thorne JG:  Risk factors for development of dysautonomia in dogs. J Am Vet Med Assoc 218:1285-1292, 2001.  [Abstract]

Canapp SO, Cohn LA, Maggs DJ, Miller MA, Kerl ME, O’Brien DP: Xerostomia, xerophthalmia, and plasmacytic infiltrates of the salivary glands (Sjögren’s -like syndrome) in a cat. J Am Vet Med Assoc 218: 59-65, 2001.  [Abstract]

Gross ME, Pope ER, Jarboe JM, O’Brien DP, Dodam JR, Polkow-Haight J:  Regional anesthesia of the infraorbital nerves during noninvasive tooth pulp stimulation in halothane anesthetized cats.  Am J Vet Res 61(10):1245-7, 2000. [Abstract]

O’Brien DP, Barshop B, Faunt KK, Johnson GC, Gibson KM, Shelton GD: Malonic aciduria in Maltese dogs: normal methylmalonic acid levels and malonyl CoA decarboxylase activity in fibroblasts.  J Inherit Metab Dis 22(8):883-890, 1999.  [Abstract]

Stoy SJ, Shibuya H, O’Brien DP. Johnson GS: A BS/I PCR/RFLP in the renin binding protein (RNBP) gene on canine chromosome X.  Anim Genet 29(4):327-328, 1998. [Abstract]

Zhou T, Shibuya H, Liu PC, O’Brien DP,  Johnson GS:  A NL-ALPHA-III PCR/RFLP in an intron of the retinitis pigmentosa gtpase regulator gene (RPGR) on the canine X chromosome. Anim Genet 29(4):330-331, 1998. [Abstract]

Chen YW, Liu PC, Shibuya H, O’Brien DP, Lubahn DB. Johnson GS: Length polymorphism in a CAG-rich coding region of the canine dentatorubro-pallidoluysian atrophy (DRPLA) gene. Anim Genet 29(3):241, 1998.  [Abstract]

Shibuya H, Liu P-C, O’Brien DP, Chen Y-W, Johnson GS: A BbvI mismatch PCR/RFLP marker for the canine huntingtin gene. Anim Genet 29:239-240,1998.  [Abstract]

O’Brien DP. Toxic and metabolic causes of seizures.  Clin Tech Small Anim Pract 13:159-166, 1998.  [Abstract]