Bo Lei
Assistant Professor - Vision Science and Ophthalmology
Veterinary Medicine and Surgery, College of Veterinary Medicine
Department of Ophthalmology, School of Medicine
University of Missouri, Columbia, MO

· MD, School of Medicine, Henan Medical University, Zhengzhou, P.R. China
· MSc (Ophthalmology and Vison Science), Henan Medical University, Zhengzhou, P. R. China
· PhD (Visual Physiology and Biophysics), Technion - Israel Institute of Technology, Haifa, Israel
· Postdoctoral Fellow, Kellogg Eye Center, University of Michigan, Ann Arbor, MI

LeiB@missouri.edu

Research emphasis:

Research focus includes investigating phototransduction and signal transmission in healthy and diseased retina and to develop non-invasive function tests for retinal disease diagnosis and therapeutic interventions. Major focus has been on outer retina and amacrine cells.

Teaching:  Vision Science

Selected publications:

Fan XF, Lei B, Zhang K, Yao G.  (2008)  Optical intrinsic signal mapping of rod- and cone-mediated visual cortex responses in mice. Vision Research. In press.

Lu W, Tan J, Zhang K, Lei B. (2008)  Computerized mouse pupil size measurement for pupillary light reflex analysis.  Comput Methods Programs Biomed.  [Epub ahead of print]  PMID: 18282634.  In press.  [Abstract]

Guo Y, Yao G, Lei B, Tan J. (2008)  A Monte-Carlo model for studying the effects of melanin concentrations on retina light absorption. J Opt Soc Am A Opt Image Sci Vis 25(2):304-11.  [Abstract]

Katz ML, Johnson GS, Tullis GE, Lei B. (2008)  Phenotypic characterization of a mouse model of juvenile neuronal ceroid lipofuscinosis (Batten Disease). Neurobiol Dis 29(2):242-53.  [Abstract]

Zhang K, Yao G, Gao Y, Hofeldt KJ, Lei B. (2007). Frequency spectrum and amplitude analysis of dark- and light-adapted oscillatory potentials in albino mouse, rat and rabbit.  Doc Ophthalmol 115:85-93.  [Abstract]

Yao G, Zhang K, Bellassai M, Chang B, Lei B. (2006).  Ultraviolet light-induced and green light-induced transient pupillary light reflex in mice. Curr Eye Res.  31(11):925-33.  [Abstract]

Lei B, Yao G, Zhang K, Hofeldt KJ, Chang B. (2006).  Study of rod- and cone-driven oscillatory potentials (OPs) in mouse.  Invest Ophthalmol Vis Sci.  47(6): 2732-2738.  [Abstract]

Lei B, Tullis GE, Kirk MD, Zhang K, Katz ML. (2006).  Ocular phenotype in a mouse gene knockout model for infantile neuronal ceroid-lipofuscinosis (CLN1).  J Neurosci Res. 84:1139-1149.  [Abstract]

Lei B, Yao G. (2006).  Spectral attenuation of crystalline lens of mouse, rat, pig and human at wavelengths from 360nm to 1020nm.  Exp Eye Res. 83:610–614.  [Abstract]

Gehlbach P, Hose S, Lei B, Zhang C, Cano M, Arora M, Neal R, Barnstable C, Goldberg MF, Zigler JS Jr, Sinha D. (2006).  Developmental abnormalities in the Nuc1 rat retina:  A spontaneous mutation that affects neuronal and vascular remodeling and retinal function.  Neuroscience. 137(2):447-461.  [Abstract]

Hyman JA, Vaegan, Lei B, Narfström KL.  (2005).  Electrophysiologic differentiation of homozygous and heterozygous Abyssinian-crossbred cats with late-onset hereditary retinal degeneration.  Am J Vet Res.  66 (11):1914-1921.  [Abstract]

Dierks D, Lei B, Zhang K, Hainsworth DP.  (2005).  Electroretinographic effects of an intravitreal injection of triamcinolone in rabbit retina.  Arch Ophthalmol.  123(11):1563-1569.  [Abstract]

Wendt KD, Lei B, Schachtman TR, Tullis GE, Ibe ME, Katz ML.  (2005)  Behavioral assessment in mouse models of neuronal ceroid lipofuscinosis using a light-cued T-maze.  Behav Brain Res. 161(2): 175-182.  [Abstract]

Bush RA, Lei B, Tao W, Raz D, Chan CC, Cox TA, Santos-Muffley M, Sieving PA.  (2004).  Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology. Invest Ophthalmol Vis Sci.  45(7):2420-30.  [Abstract]

Zhang C, Lei B, Lam TT, Yang F, Sinha D, Tso MO.  (2004).  Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration.  Invest Ophthalmol Vis Sci. 45(8):2753-59.  [Abstract]

Lei B. (2003).  The ERG of guinea pig (Cavis porcellus): comparison with I-type monkey and E-type rat.  Doc Ophthalmol. 106(3): 243-249.  [Abstract]

Zemel E, Lei B, Perlman I.  (2001).  NADPH diaphorase activity in the rabbit retina is modulated by glutamatergic pathways.  J Comp Neurology.  431(1):28-38.  [Abstract]

Hrach CJ, Johnson MW, Hassan AS, Lei B, Sieving PA, Elner VM.  (2000).  Retinal toxicity of commercial intravitreal tissue plasminogen activator solution in cat eyes.  Arch Ophthalmol. 118:659-663.  [Abstract]

Perlman I, Segev E, Mazawi N, Merhav-Armon T, Lei B, Leibu R.  (2001).  Visual evoked cortical potential can be used to differentiate between uncorrected refractive error and macular disorders.  Doc Ophthalmol. 102(1):41-62.  [Abstract]

Jamison JA, Bush RA, Lei B, Sieving PA.  (2001).  Characterization of the rod photoresponse isolated from the dark-adapted primate ERG.  Vis Neurosci. 18(3):445-455.  [Abstract]

Lei B, Bush RA, Milam AH, Sieving PA.  (2000).  Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo.  Invest Ophthalmol Vis Sci. 41: 262-266. [Abstract]

Lei B, Perlman I.  (1999).  The contributions of voltage- and time-dependent potassium conductance to the electroretinogram in rabbits.  Vis Neurosci. 16: 743-754.  [Abstract]

Perlman I, Lei B, Zemel E, Itzhaki A.  (1997).  The effects of barium on retinal function in the rabbit.   In:  Basic and Clinical Applications of Vision Science.   Lakshminarayanan V. (ed), Kluwer Academic Publishers: Dordrecht, Netherlands, pp. 171-175.

Zemel E, Eyal O, Lei B, Perlman I.  (1996).  NADPH diaphorase reactivity in the mammalian retina is modulated by the state of visual adaptation.  Vis Neurosci. 13:863-871.  [Abstract]

Zemel E, Loewenstein A, Lei B, Lazar M, Perlman I.  (1995).  Ocular pigmentation protects the rabbit retina from gentamicin-induced toxicity.  Invest Ophthalmol Vis Sci.  36:1875-1884.  [Abstract]