James L. Cook
Associate Professor of Orthopaedic Surgery
    and William C. Allen Endowed Scholar for Orthopaedic Research
Director, Comparative Orthopaedic Laboratory

· BS (Mathematics Education), Florida State University, Tallahassee, FL
· DVM (magna cum laude), University of Missouri, Columbia, MO
· PhD (Pathobiology), University of Missouri, Columbia, MO

· Diplomate, American College of Veterinary Surgeons

CookJL@missouri.edu

Positions:

• Director of Basic Science Studies and Lab Operations, Comparative Orthopaedic Laboratory, University of Missouri
• Associate Professor, Small Animal Orthopaedics, Department of Veterinary Medicine and Surgery, University of Missouri Veterinary Medical Teaching Hospital
• Associate Professor, Orthopaedic Surgery, Department of Orthopaedic Surgery, School of Medicine, University of Missouri Hospitals and Clinics
• William C. Allen Endowed Scholar for Orthopaedic Research, Department of Orthopaedic Surgery, School of Medicine, University of Missouri Hospitals and Clinics
• Adjunct Professor, Department of Pathobiology, College of Veterinary Medicine, University of Missouri

Research emphasis:

All of my research is coordinated through the Comparative Orthopaedic Laboratory, which I direct. The focus of my research is centered on disorders of articular and meniscal cartilage. My work includes in vivo and in vitro study of cartilage in health and disease. Specific avenues of research include three-dimensional chondrocyte culture, osteoarthritis models, meniscal replacement and regeneration, articular cartilage resurfacing, creation of functional growth plates, and total joint replacement. Laboratory assessment modalities include a wide range of techniques from the DNA and mRNA level to biomechanical testing and clinical trials. Current funding is both extramural and intramural.

Honors and Distinctions:

• Pfizer Award for Research Excellence
• Golden Chalk Award - Graduate Professional Council, University of Missouri.
• Hohn-Johnson Research Award. Veterinary Orthopedic Society
• Norden Distinguished Teacher Award
  

Teaching:  Small Animal Orthopaedic Surgery

Selected publications:

Cogar SM, Cook CR, Curry SL, Grandis A, Cook JL.  Prospective evaluation of techniques for differentiating shoulder pathology as a source of forelimb lameness in medium and large breed dogs.  Vet Surg 2008; 37(2):132-41.  [Abstract]

Cook JL, Fox DB, Kuroki K, Jayo M, De Deyne PG.  In vitro and in vivo comparison of five biomaterials used for orthopedic soft tissue augmentation.  Am J Vet Res 2008; 69(1):148-56.  [Abstract]

Dismukes DI, Tomlinson JL, Fox DB, Cook JL, Song KJ.  Radiographic measurement of the proximal and distal mechanical joint angles in the canine tibia.  Vet Surg 2007; 36(7):699-704.  [Abstract]

Cook JL, Fox DB.  A novel bioabsorbable conduit augments healing of avascular meniscal tears in a dog model.  Am J Sports Med 2007; 35(11):1877-87.  [Abstract]

Tomlinson J, Fox D, Cook JL, Keller GG.  Measurement of femoral angles in four dog breeds. Vet Surg 2007; 36(6):593-98.  [Abstract]

DePuy T, Howard R, Keegan K, Wilson D, Kramer J, Cook JL, Childers MK.  Effects of intra-articular botulinum toxin type A in an equine model of acute synovitis: a pilot study.  Am J Phys Med Rehabil 2007; 86(10):777-83.  [Abstract]

Cook JL.  Future trends in joint replacement and tissue engineering in small animal orthopedics.  Vet Surg 2007; 36(4):287-78. [No abstract available]  

Witsberger TH, Cook JL, Cook CR.  What is your diagnosis? Hip joint luxation with secondary osteoarthritis and pseudoarthrosis. J Am Vet Med Assoc 2007; 230(11):1631-32. [No abstract available]  

Cook JL.  Outcomes-based patient care in veterinary surgery:  What is an outcome measure?  Vet Surg 2007; 36(3):187-89. [No abstract available]

Scott A, Cook JL, Hart DA, Walker DC, Duronio V, Khan KM.  Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats.  Arthritis Rheum 2007; 56(3):871-81  [Abstract]

Schulz KS, Cook JL, Kapatkin AS, Brown DC.  Evidence-based surgery: time for change.  Vet Surg 2006; 35(8):697-99.   Erratum in: Vet Surg 2007; 36(2):185   [No Abstract Available]

Stoker AM, Cook JL, Kuroki K, Fox DB.  Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs.  J Orthop Surg 2006; 1:8   [Abstract]

Cook JL.  Outcomes-based patient care in veterinary surgery: What is an outcome measure?  Vet Surg 2007; 36(3):187-89. [Abstract]

Cook JL.  Future trends in joint replacement and tissue engineering in small animal orthopedics.  Vet Surg 2007; 36(4):287-88.  [Abstract]

Thieman KM, Tomlinson JL, Fox DB, Cook C, Cook JL.  Effect of meniscal release on rate of subsequent meniscal tears and owner-assessed outcome in dogs with cruciate disease treated with tibial plateau leveling osteotomy.  Vet Surg 2006; 35(8):705-10.  [Abstract]

Hughes MS, Kazmier P, Burd TA, Anglen J, Stoker AM, Kuroki K, Carson WL, Cook JL.  Enhanced fracture and soft-tissue healing by means of anabolic dietary supplementation.  J Bone Joint Surg Am 2006; 88(11):2386-94.  [Abstract]

Cook JL, Fox DB, Malaviya P, Tomlinson JL, Farr J, Kuroki K, Cook CR.  Evaluation of small intestinal submucosa grafts for meniscal regeneration in a clinically relevant posterior meniscectomy model in dogs.  J Knee Surg. 2006;19(3):159-67. [Abstract]

Fox DB, Cook JL, Kuroki K, Cockrell M.  Effects of dynamic compressive load on collagen-based scaffolds seeded with fibroblast-like synoviocytes.  Tissue Eng 2006; 12(6):1527-37.  [Abstract]

Stoker AM, Cook JL, Kuroki K, Fox DB.  Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs. J Ortho Surg Res 2006;1:8.  [Abstract]

Cook JL, Fox DB, Malaviya P, Tomlinson JL, Kuroki K, Cook CR, Kladakis S.  Long-term evaluation of treatment of large meniscal defects using small intestinal submucosa in a dog model. Am J Sports Med 2006; 34(1):32-42.  [Abstract]

Greenberg DD, Stoker A, Kane S, Cockrell M, Cook JL.  Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis.  Osteoarthritis Cartilage 2006;14(8):814-22.  [Abstract]

Fox DB, Tomlinson JL, Cook JL, Breshears LM.  Principles of uniapical and biapical radial deformity correction using dome osteotomies and the center of rotation of angulation methodology in dogs.  Vet Surg 2006; 35(1):67-77.  Erratum in: Vet Surg 2006; 35(3):315-16.  [Abstract]

Cook JL. The current status of treatment for large meniscal defects.  Clin Orthop Rel Res 2005; 495:88-95.  [Abstract]

Kuroki K, Cook JL, Stoker AM, Turnquist SE, Kreeger JM, Tomlinson JL.  Characterizing osteochondrosis in the dog: Potential roles for matrix metalloproteinases and mechanical load in pathogenesis and disease progression.  Osteoarthritis Cartilage, 2005; 13:225-34.   [Abstract]

Cook JL, Kuroki K, Kenter K, Marberry K, Brawner T, Geiger T, Jayabalan P, Bal BS.  Bipolar and monopolar radiofrequency treatment of osteoarthritic knee articular cartilage: acute and temporal effects on cartilage compressive stiffness, permeability, cell synthesis, and extracellular matrix composition.  J Knee Surg 2004;17(2):99-108.  [Abstract]

Cook JL, Marberry KM, Kuroki K, Kenter K.  Assessment of cellular, biochemical, and histologic effects of bipolar radiofrequency treatment of canine articular cartilage. Am J Vet Res 2004; 65(5):604-09.  [Abstract]

Fox DB, Cook JL, Arnoczky SP, Tomlinson JL, Kuroki K, Kreeger JM, Malaviya P.  Fibrochondrogenesis of free intraarticular small intestinal submucosa scaffolds. Tissue Eng 2004; 10(1-2):129-37. [Abstract]

Ray A, Kumar D, Shakya A, Brown CR, Cook JL, Ray BK.  Serum amyloid A-activating factor-1 (SAF-1) transgenic mice are prone to develop a severe form of inflammation-induced arthritis. J Immunol 2004; 173:4684-91.  [Abstract]

Kuroki K, Cook JL, Kreeger JM. Effects of tissue inhibitor of metalloproteinases on canine chondrocytes cultured in vitro with tumor necrosis factor-alpha.  Am J Vet Res 2004; 65:1611-15.  [Abstract]

Kuroki K, Cook JL, Kreeger JM, Tomlinson JL. The effects of TIMP-1 and -2 on canine chondrocytes cultured in three-dimensional agarose culture system. Osteoarthritis Cartilage 2003; 11(9):625-35. [Abstract]

Cook JL, Williams N, Kreeger JM, Peacock JT, Tomlinson JL.  Biocompatibility of three-dimensional chondrocyte grafts in large tibial defects of rabbits.  Am J Vet Res 2003; 64(1):12-20. [Abstract]

Ray A, Kuroki K, Cook JL, Bal BS, Kenter K, Aust G, Ray BK. Induction of matrix metalloproteinase-1 gene expression is regulated by inflammation-responsive transcription factor serum amyloid A-activating factor-1 (SAF-1) in osteoarthritis. Arthritis Rheum 2002; 48:134-145. [Abstract]

Beatty MW, Ojha AK, Cook JL, Alberts LR, Mahanna GK, Iwasaki LR, Nickel JC.  Small intestinal submucosa versus salt-extracted polyglycolic acid-poly-L-lactic acid: a comparison of neocartilage formed in two scaffold materials. Tissue Eng 2002;8:955-68. [Abstract]

Kuroki K, Cook JL, Kreeger JM.  Mechanisms of action and potential uses of hyaluronan in dogs with osteoarthritis. J Am Vet Med Assoc 2002; 221:944-950. [Abstract]

Kuroki K, Kreeger JM, Cook JL, Tomlinson JL, Johnson GC, Pace LW, Turnquist SE, Turk JR, Ramos JA, Miller MA.  Immunohistochemical study of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs. Am J Vet Res 2002;63(9):1285-291. [Abstract]

Fox DB, Cook JL, Kreeger JM, Beissenherz M, Henry CJ.  Canine synovial sarcoma: A retrospective assessment of described prognostic criteria in 16 cases (1994-99). J Am Anim Hosp Assoc 2002; 38:347-55. [Abstract]

Tomlinson JL, Cook JL. Effects of degree of acetabular rotation after triple pelvic osteotomy on the position of the femoral head in relationship to the acetabulum. Vet Surg 2002, 31:398-403. [Abstract]

Kuroki K, Cook JL, Tomlinson JL, Kreeger JM. In vitro characterization of chondrocytes isolated from naturally occurring osteochondrosis lesions of the humeral head of dogs. Am J Vet Res 2002; 63:186-93. [Abstract]

Fox DB, Cook JL. Synovial fluid markers of osteoarthritis in dogs. J Am Vet Med Assoc 2001; 219(6):756-761. [Abstract]

Tomlinson JT, Cook JL, Kuroki K, Kreeger JM, Anderson MA. Biochemical characterization of cartilage affected by osteochondritis dissecans in the humeral head of dogs. Am J Vet Res 2001; 62(6):876-81. [Abstract]

Cook JL, Tomlinson JL, Arnoczky SP, Fox DB, Reeves Cook C, Kreeger JM. Kinetic study of the replacement of porcine small intestinal submucosa grafts and the regeneration of meniscal-like tissue in large avascular meniscal defects in dogs. Tissue Eng 2001;7(3):321-34. [Abstract]

Cook JL, Anderson CC, Kreeger JM, Tomlinson JL.  In vitro osteoarthritis model using IL-1ß in three-dimensional chondrocyte culture. Am J Vet Res 2000;61(7):766-70. [Abstract]

Cook JL, Tomlinson JL, Kreeger JM, Cook CR.  Induction of meniscal regeneration in dogs using a novel biomaterial. Am J Sports Med 1999;27(5):658-65. [Abstract]

Cook JL, Kreeger JM, Payne JT, Tomlinson JL. Three-dimensional culture of canine articular chondrocytes on multiple transplantable substrates. Am J Vet Res 1997;58(4):419-24. [Abstract]